تفاصيل الوثيقة
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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Systematic administration of interferon-alpha (INF-alpha) is considered as the backbone of HCV therapy since 1991. Interferon (IFN)
therapy can cause vasculitis, glomerulonephritis, cryoglobulinemia and certain other autoimmune diseases such as sialoadentitis, lichen
planus and thyroiditis. Related to the factors of interferons, extensively studied gland is thyroid gland. A strong association was observed
between thyroid disease and HCV patient when they were exposed to IFN therapy. Vitamin D, malondialdehyde (MDA), thyroid
hormones and auto antibodies were biochemically assessed from the venous blood of seventy five HCV patients and fifty healthy controls.
The results of all parameters were analyzed by independent sample t-test. The results of the study demonstrated a clear picture that the
levels of vitamin D decreased as compared to control but increases in case of MDA. The levels of antibody titer represent that
thyroglobulin-antibody (TGAb) thyroid peroxidase-antibody (TPOAb) as well as thyroid stimulating hormone receptor-antibody
(TSHRAb) were raised in the patients suffering from HCV with thyroid dysfunction as compared to control. Similarly, the levels of thyroid
hormones were also elevated in the HCV patients. Antibodies generated against thyroidal enzymes leads to impaired function of these
enzymes thus causing decreased synthesis of thyroid hormones. As exogenous INF triggers the release of cytokines that mediate the
recruitment of immune cells with increased production of inflammatory markers lead to production of lytic granules which have direct
toxic action on thyroid cells and ultimately increased lipid peroxidation of thyrocytes. The results of the present study clearly
demonstrated that the decreased levels of vitamin D in HCV patients receiving IFN therapy were responsible to induce autoimmunity
against thyroid gland and adjutant therapy may be helpful to alleviate the possible thyroid disorders. |
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ردمد |
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2814-9047 |
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اسم الدورية |
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Bioinformation |
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المجلد |
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12 |
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العدد |
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3 |
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سنة النشر |
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1437 هـ
2016 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Thursday, July 20, 2017 |
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الباحثون
| Mahwish Arooj | Arooj, Mahwish | باحث | دكتوراه | |
| Arif Malik | Malik, Arif | باحث | دكتوراه | |
| Abdul Basit | Basit, Abdul | باحث | دكتوراه | |
| Mahmood Husain Qazi | Qazi, Mahmood Husain | باحث | دكتوراه | |
| Muhammad Asif | Asif, Muhammad | باحث | دكتوراه | |
| Mohammad Sarwar Jamal | Jamal, Mohammad Sarwar | باحث | دكتوراه | |
| Maged Mostafa Mahmoud | Mahmoud, Maged Mostafa | باحث | دكتوراه | |
| Hani Choudhry | Choudhry, Hani | باحث | دكتوراه | |
| Peter Natesan Pushparaj | Pushparaj, Peter Natesan | باحث | دكتوراه | |
| Mahmood Rasool | Rasool, Mahmood | باحث | دكتوراه | mahmoodrasool@yahoo.com |
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